Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Scelo, G. ; Purdue, M. P. ; Brown, K. M. ; Johansson, M. ; Wang, Zheng-Yu ; Eckel-Passow, J. E. ; Ye, Yuzhen ; Hofmann, J. N. ; Choi, Jacqueline ; Foll, M. ; Gaborieau, V. ; Machiela, M. J. ; Colli, L. M. ; Li, Pengyun ; Sampson, J. N. ; Abedi-Ardekani, B. ; Besse, C. ; Blanche, H. ; Boland, A. ; Burdette, L. ; Chabrier, A. ; Durand, G. ; Calvez-Kelm, F. Le ; Prokhortchouk, E. ; Robinot, N. ; Skryabin, K. G. ; Wozniak, M. B. ; Yeager, M. ; Basta-Jovanovic, G. ; Dzamic, Z. ; Foretova, L. ; Holcatova, I. ; Janout, V. ; Mates, D. ; Mukeriya, A. ; Rascu, S. ; Zaridze, D. ; Bencko, V. ; Cybulski, C. ; Fabianova, E. ; Jinga, V. ; Lissowska, J. ; Lubinski, J. ; Navratilova, M. ; Rudnai, P. ; Szeszenia-Dabrowska, N. ; Benhamou, S. ; Cancel-Tassin, G. ; Cussenot, O. ; Baglietto, L. ; Boeing, H. ; Khaw, K. T. ; Weiderpass, E. ; Ljungberg, B. ; Sitaram, R. T. ; Bruinsma, F. ; Jordan, Stephen James ; Severi, G. ; Winship, I. ; Hveem, K. ; Vatten, L. J. ; Fletcher, T. ; Koppova, K. ; Larsson, S. C. ; Wolk, A. ; Banks, R. E. ; Selby, P. J. ; Easton, D. F. ; Pharoah, P. ; Andreotti, G. ; Freeman, L. E. B. ; Koutros, S. ; Albanes, D. ; Mannisto, S. ; Weinstein, S. ; Clark, P. E. ; Edwards, T. L. ; Lipworth, L. ; Gapstur, S. M. ; Stevens, V. L. ; Carol, H. ; Freedman, M. L. ; Pomerantz, M. M. ; Cho, E. ; Kraft, P. ; Preston, M. A. ; Wilson, Kari Michelle ; Gaziano, J. Michael ; Sesso, H. D. ; Black, A. ; Freedman, N. D. ; Huang, William Y ; Anema, J. G. ; Kahnoski, R. J. ; Lane, B. R. ; Noyes, S. L. ; Petillo, D. ; Teh, B. T. ; Peters, U. ; White, Eva Roa ; Anderson, G. L. ; Johnson, L. ; Luo, J. ; Buring, J. ; Lee, I-Min ; Chow, Wong-Ho ; Moore, L. E. ; Wood, C. ; Eisen, T. ; Henrion, M. ; Larkin, J. ; Barman, P. ; Leibovich, B. C. ; Choueiri, T. K. ; Lathrop, G. M. ; Rothman, N. ; Deleuze, Jean-Francois ; McKay, J. D. ; Parker, A. S. ; Wu, X. ; Houlston, R. S. ; Brennan, P. ; Chanock, S. J.

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10−$^{10} $), 3p22.1 (rs67311347, P=2.5 × 10−$^8$), 3q26.2 (rs10936602, P=8.8 × 10−$^9$), 8p21.3 (rs2241261, P=5.8 × 10−$^9$), 10q24.33-q25.1 (rs11813268, P=3.9 × 10−$^8$), 11q22.3 (rs74911261, P=2.1 × 10−$^{10}$) and 14q24.2 (rs4903064, P=2.2 × 10−$^{24}$). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.


Publication Date:
Jun 09 2017
Date Submitted:
Aug 10 2018
ISSN:
2041-1723
Citation:
Nature Communications
8
Note:
A freely accessible, full text version is available using the link(s) in External Resources.
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 Record created 2018-08-10, last modified 2019-04-03


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