Lipid Bilayer Disruption by Amphiphilic Janus Nanoparticles: The Role of Janus Balance

Amphiphilic nanoparticles are known to cause defects in lipid bilayers. But we have shown recently that their disruptive effects are significantly enhanced when surface charges and hydrophobic groups are spatially segregated on opposite hemispheres of a single particle. Using the same amphiphilic cationic/hydrophobic Janus particle system, here we investigate the role of the hydrophilic-lipophilic balance of the particles (namely the Janus balance) in their interaction with zwitterionic lipid bilayers. We show that Janus nanoparticles induce holes in lipid bilayers only when the hydrophobic side of particles occupies 20% or more of their surfaces. Beyond this threshold, the larger the hydrophobic surface area, the more attractive the particles are to lipid bilayers and the lower particle concentration is needed for causing defects in the bilayers. The results establish a quantitative relationship between the surface coverage of hydrophobicity on Janus particles and the particle-induced disruption to lipid membranes.


Publication Date:
Sep 21 2018
Date Submitted:
Jul 10 2019
Pagination:
12387-12393
ISSN:
0743-7463
Citation:
Langmuir
34
41

Note: The file is under embargo until: 2019-12-31



 Record created 2019-07-10, last modified 2019-07-11

postprint:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)