Melting proteins confined in nanodroplets with 10.6 $\mu$m light provides clues about early steps of denaturation

Ubiquitin confined within nanodroplets was irradiated with a variable-power CO$_2$ laser. Mass spectrometry analysis shows evidence for a protein “melting”-like transition within droplets prior to solvent evaporation and ion formation. Ion mobility spectrometry reveals that structures associated with early steps of denaturation are trapped because of short droplet lifetimes.


Publication Date:
Mar 27 2019
Date Submitted:
Jul 01 2019
Pagination:
3270-3273
Citation:
Chemical Communications
54
26
External Resources:




 Record created 2019-07-01, last modified 2019-07-24


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