Traversing Steric Limitations by Cooperative Lewis Base/Palladium Catalysis: An Enantioselective Synthesis of α-Branched Esters Using 2-Substituted Allyl Electrophiles

Cooperative catalysis enables the direct enantioselective α-allylation of linear prochiral esters using 2-substituted allyl electrophiles. Critical to the successful development of the method was the recognition that metal-centered reactivity and the source of enantiocontrol are independent. This feature is unique to simultaneous catalysis events and permits logical tuning of the supporting ligands without compromising enantioselectivity.


Publication Date:
Apr 27 2018
Date Submitted:
Jun 28 2019
Pagination:
7800-7803
Citation:
Angewandte Chemie International Edition
57
26
External Resources:




 Record created 2019-06-28, last modified 2019-07-24


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