Enantioselective α-Allylation of Acyclic Esters using B(pin)-Substituted Electrophiles: Independent Regulation of Stereocontrol Elements via Cooperative Pd/Lewis Base Catalysis

Cooperation between a Lewis base and Pd catalyst enables the direct enantioselective α-functionalization of aryl and vinyl acetic acid esters using a bifunctional B(pin)-substituted electrophile. Critical to the success of this method was the recognition that both catalysts could control the necessary stereochemical aspects; the Lewis base catalyst controls the enantioselectivity of the reaction, whereas the Pd catalyst regulates alkenyl-B(pin) configuration. This is the first example of using cooperative catalysis to control both stereochemical features during Pd-catalyzed allylic alkylation.


Publication Date:
Sep 03 2018
Date Submitted:
Jun 28 2019
Pagination:
14378-14381
Citation:
Chemistry - A European Journal
24
54
External Resources:




 Record created 2019-06-28, last modified 2019-07-24


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