We consider the problem of identifying the most influential nodes for a spreading process on a network when prior knowledge about structure and dynamics of the system is incomplete or erroneous. Specifically, we perform a numerical analysis where the set of top spreaders is determined on the basis of prior information that is artificially altered by a certain level of noise. We then measure the optimality of the chosen set by measuring its spreading impact in the true system. Whereas we find that the identification of top spreaders is optimal when prior knowledge is complete and free of mistakes, we also find that the quality of the top spreaders identified using noisy information doesn't necessarily decrease as the noise level increases. For instance, we show that it is generally possible to compensate for erroneous information about dynamical parameters by adding synthetic errors in the structure of the network. Further, we show that, in some dynamical regimes, even completely losing prior knowledge on network structure may be better than relying on certain but incomplete information.