Family History of Cancer and Risk of Biliary Tract Cancers: Results from the Biliary Tract Cancers Pooling Project

Dyke, A L Van ; Langhamer, M S ; Zhu, B ; Pfeiffer, R M ; Albanes, D ; Andreotti, G ; Freeman, L E Beane ; Chan, A T ; Freedman, N D ; Gapstur, S M ; Giles, G G ; Grodstein, F ; Liao, L M ; Luo, Juhua ; Milne, R L ; Monroe, K R ; Neuhouser, M L ; Poynter, J N ; Purdue, M P ; Robien, K ; Schairer, C ; Sinha, R ; Weinstein, S ; Zhang, X ; Petrick, J L ; McGlynn, K A ; Campbell, P T ; Koshiol, J

Background Although some familial cancer syndromes include biliary tract cancers (BTCs) (cancers of the gallbladder, intrahepatic and extrahepatic bile ducts, and ampulla of Vater), the few studies that have examined the relationships between family history of cancer (FHC) and BTCs have reported inconclusive findings. The objective of this study was to investigate the associations of FHC with risk of BTC in the Biliary Tract Cancers Pooling Project (BiTCaPP). Methods We used Cox proportional hazards regressions models to estimate HRs and 95% confidence intervals for associations between FHC (any, 1st degree, in female relative, in male relative, relative with gastrointestinal cancer, and relative with hormonally-related cancer) and BTC risk by anatomic site within the biliary tract, adjusting for sex and race/ethnicity. Sensitivity analyses were conducted that restricted to studies reporting cholecystectomy data and to people without a history of cholecystectomy. Results Data on FHC were available from 12 prospective studies within BiTCaPP, which collectively contributed 2,246 cases (729 gallbladder, 345 intrahepatic and 615 extrahepatic bile duct, and 385 ampulla of Vater cancers) with 21,706,107 person-years of follow-up. A marginal, inverse association between FHC and gallbladder cancer was driven to the null when analysis was restricted to studies reporting cholecystectomy data and to people without a history of cholecystectomy. FHC was not associated with risk of BTC at the other anatomic sites. Conclusions These findings do not support an association between FHC and BTCs.


Publication Date:
Jan 16 2018
Date Submitted:
Jun 28 2019
Pagination:
348-351
Citation:
Cancer Epidemiology, Biomarkers and Prevention
27
3
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 Record created 2019-06-28, last modified 2019-08-05


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